Comparison of Retinal Nerve Fiber Layer Measurements between NTG and HTG using GDx-VCC.
- Author:
JI Yong JUNG
1
;
Jae Hyung KIM
;
Michael S KOOK
Author Information
- Publication Type:Original Article ; Comparative Study
- Keywords: Normal-tension glaucoma (NTG); High-tension glaucoma (HTG); scanning laser polarimetry with variable corneal compensation (GDx-VCC)
- MeSH: Visual Fields; Severity of Illness Index; Retrospective Studies; Retinal Ganglion Cells/*pathology; Perimetry/*methods; Nerve Fibers/*pathology; Middle Aged; Lasers/*diagnostic use; Intraocular Pressure/*physiology; Humans; Glaucoma, Open-Angle/*pathology/physiopathology; Follow-Up Studies; Aged
- From:Korean Journal of Ophthalmology 2006;20(1):26-32
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: To compare quantitative polarimetric measurements in eyes with NTG and HTG using GDx-VCC. Both groups were matched by age and glaucoma stage based on the Humphrey visual field test. METHODS: We retrospectively reviewed the records of 146 patients who underwent Humphrey field analysis (HFA) and GDx-VCC. We compared outcomes of retinal nerve fiber layer (RNFL) parameters among the three groups by ANOVA and between each pair of groups using the Tukey-Kramer Post-Hoc test. We also evaluated the sensitivity and specificity of GDx-VCC in detecting glaucoma in each group. RESULTS: The mean age and HFA mean deviation (MD) were 55.6+/-9.5 years and -0.8+/-1.5 dB in 47 control patients, 59.4+/-9.0 years and -5.77+/-4.38 dB in 49 NTG patients, and 59.4+/-11.7 years and -8.09+/-6.77 dB in 51 HTG patients, respectively. All thickness parameters were lower in HTG patients compared to NTG patients, but there were no significant differences in ratio parameters between age-matched early HTG and NTG patients. The sensitivity of GDx-VCC was significantly higher in both early and total HTG patients compared to the respective groups of NTG patients. CONCLUSIONS: Compared to eyes with NTG, eyes with HTG showed reduced RNFL thickness and ratio parameters when patients were age and visual field matched. GDx-VCC appeared to be more sensitive in detecting RNFL damage in HTG patients.
