The Expression of Extracellular Matrix mRNA in the Chondrocytes of the Femoral Head Affected by Avascular Necrosis.
10.5371/jkhs.2008.20.4.320
- Author:
Whan Young CHUNG
1
;
Woo Suk LEE
;
Sang Bum KIM
;
In Tak BAE
;
Won Ki PARK
Author Information
1. Department of Orthopaedic Surgery, Konyang University College of Medicine, Daejeon, Korea. wsleeos@kyuh.co.kr
- Publication Type:Original Article
- Keywords:
Avacular necrosis;
Chondrocytes;
Type II collagen;
Aggrecan;
VEGF-A;
PEDF
- MeSH:
Aggrecans;
Cartilage;
Cartilage, Articular;
Chondrocytes;
Collagen Type II;
Extracellular Matrix;
Head;
Humans;
Necrosis;
RNA, Messenger;
Vascular Endothelial Growth Factor A
- From:Journal of the Korean Hip Society
2008;20(4):320-325
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The aim of this study was to evaluate the expression of type II collagen, aggrecan, VEGF-A and PEDF mRNAs in the human chondrocytes derived from the articular cartilage of the femoral heads with avacular necrosis (AVN). MATERIALS AND METHODS: We cultured human chondrocytes that were primarily derived from the articular cartilage of femoral heads with AVN. We evaluated the mRNA expression of type II collagen, aggrecan, VEGF-A and PEDF. RESULTS: The chondrocytes of the AVN group showed decreased expressions of type II collagen mRNA and aggrecan mRNA (p<0.05). The expression of VEGF-A mRNA and PEDF mRNA in the AVN group was the same as that of the normal group (p>0.05). CONCLUSION: The cartilage matrix's formation ability was found to be decreased in the chondrocytes of the femoral heads affected by AVN.
