The Non-glycemic Effects of SGLT2 Inhibitor.
10.4093/jkd.2014.15.3.151
- Author:
Dae Ho LEE
1
Author Information
1. Department of Internal Medicine, Wonkwang University School of Medicine & Hospital, Iksan, Korea. drhormone@naver.com
- Publication Type:Original Article
- Keywords:
Diabetes mellitus;
Sodium glucose cotransporter 2;
Antidiabetic agent
- MeSH:
Aldosterone;
Blood Pressure;
Body Weight;
Diabetes Mellitus;
Eating;
Glucose;
Incretins;
Kidney;
Leptin;
Sodium;
Uric Acid
- From:Journal of Korean Diabetes
2014;15(3):151-157
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Sodium glucose cotransporter 2 (SGLT2) inhibitors have recently been introduced as a new class of anti-diabetic agents. In addition to their glycemic action, SGLT2 inhibitors also have a number of non-glycemic effects that may contribute to renal and/or cardiovascular benefits. These include effects on tubuloglomerular feedback in the kidney, body weight, blood pressure, and serum uric acid. Other non-glycemic effects of SGLT2 inhibitors that need to be further studied include the effects on lipid profiles, food intake, and secretion of hormones such as leptin, incretins, and aldosterone. Also, the exact mechanisms of various non-glycemic actions should be further studied. Additionally, SGLT2 inhibitor therapy in combination with other drugs may have beneficial glycemic and non-glycemic effects.
