Comparison of the Efficacy of Dipeptidylpeptidase-4 Inhibitors Between Asian and Non-Asian Populations.
10.4093/jkd.2013.14.3.133
- Author:
Yeong Gi KIM
1
;
Young Min CHO
Author Information
1. Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. ymchomd@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Dipeptidylpeptidase-4 inhibitor;
Type 2 diabetes mellitus;
Asian population;
Body mass index
- MeSH:
Asian Continental Ancestry Group;
Body Mass Index;
Diabetes Mellitus, Type 2;
Glucose;
Humans;
Incretins;
Insulin;
Insulin Resistance
- From:Journal of Korean Diabetes
2013;14(3):133-137
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Type 2 diabetes is different between Asian and non-Asian populations. Compared with their Caucasian counterparts, Asian patients with type 2 diabetes have the characteristics of lower body mass index, lower insulin secretory response, and a lower degree of insulin resistance. Furthermore, a recent study revealed that the incretin effect is not decreased in Korean patients with type 2 diabetes compared with normal glucose tolerance. The HbA1c lowering efficacy of dipeptidylpeptidase-4 inhibitors, which enhances active incretin hormones, is greater in Asian people than in non-Asian people, which could be ascribed to their lower body mass indexes. Therefore, doctors should take these differing characteristics of type 2 diabetes in Asian patients into account for customized anti-diabetes therapy.
