Bone and Energy Metabolism.
10.4093/jkd.2013.14.4.174
- Author:
Sujin LEE
1
;
Yumie RHEE
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. yumie@yuhs.ac
- Publication Type:Original Article
- Keywords:
Bone;
Energy metabolism;
Leptin;
Serotonin;
Neurotransmitter agents;
Osteocalcin
- MeSH:
Adipocytes;
Bone Remodeling;
Central Nervous System;
Energy Metabolism*;
Glucose;
Leptin;
Metabolism;
Neurotransmitter Agents;
Osteoblasts;
Osteocalcin;
Serotonin
- From:Journal of Korean Diabetes
2013;14(4):174-177
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Bone remodeling requires a large amount of energy, and is regulated by various hormones. Leptin, produced by adipocytes, is a well-known regulator of energy balance and is also involved in controlling bone mass through interaction with the central nervous system. Serotonin, downstream of leptin, is also emerging as a candidate for controlling energy balance and bone metabolism. Currently, bone is also considered to be an endocrine regulator of energy metabolism. Osteocalcin, secreted from osteoblasts, is known to be a key regulator of glucose and fat metabolism. In this review, we describe a novel concept that asserts that there exists a biological link between bone and energy metabolism, and we summarize what is currently known about the relationship between bone and energy metabolism.
