A Case of Gabapentin-induced Myoclonus in a Type 2 Diabetic Patient with End-stage Renal Disease.
10.4093/jkd.2011.12.3.171
- Author:
Eun Yeong CHOE
1
;
Byung Wan LEE
;
Kyeong Hye PARK
;
Hannah SEOK
;
Daham KIM
;
Eun Seok KANG
;
Bong Soo CHA
;
Hyun Chul LEE
Author Information
1. Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea. bwanlee@yuhs.ac
- Publication Type:Case Report
- Keywords:
Gabapentin;
Myoclonus;
Diabetic neuropathies;
Chronic renal failure
- MeSH:
Aged;
Amines;
Anticonvulsants;
Brain;
Brain Injuries;
Cyclohexanecarboxylic Acids;
Diabetic Neuropathies;
Epilepsy, Post-Traumatic;
gamma-Aminobutyric Acid;
Humans;
Kidney Failure, Chronic;
Male;
Myoclonus;
Renal Dialysis;
Renal Insufficiency
- From:Journal of Korean Diabetes
2011;12(3):171-173
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Development of myoclonus can manifest as a side effect of antiepileptic drugs in subjects with preexisting epilepsy, post-traumatic brain injury, encephalopathy, or focal and multifocal brain lesions. A 69-year-old male showed new onset severe myoclonus and confusion two days after taking 1200 mg gabapentin. The patient had end-stage renal disease secondary to type 2 diabetes and was receiving hemodialysis twice a week. After increasing hemodialysis to three times a week and discontinuing gabapentin, myoclonus spontaneously resolved. Here we report the first case of myoclonus in a Korean subject with diabetic renal failure. We recommend caution in the administration of gabapentin for diabetic subjects with renal disease.
