The Effects of Diabetes on Risk of Infection.
- Author:
Ji A SEO
1
Author Information
- Publication Type:Randomized Controlled Trial ; Original Article
- Keywords: Diabetes mellitus; Hyperglycemia; Infection
- MeSH: Colon; Diabetes Mellitus; Humans; Hyperglycemia; Mucormycosis; Otitis Media; Prospective Studies; Skin
- From:Journal of Korean Diabetes 2017;18(1):14-19
- CountryRepublic of Korea
- Language:Korean
- Abstract: A relationship between diabetes and infection has long been accepted clinically. Host-specific factors that are thought to predispose diabetic patients to infection include hyperglycemia-related impairment of the immune response, vascular insufficiency, diabetic peripheral and autonomic neuropathy, and skin and mucosal colonization of pathogens. Some uncommon but life-threatening infections (e.g., malignant otitis media, rhinocerebral mucormycosis, gangrenous cholecystitis) occur almost exclusively in people with diabetes. Previous large population-based observational studies have reported strong associations between higher HbA1c and infection risks for both type 1 and type 2 diabetes. However, the potential of better long-term glycemic control to prevent infection remains controversial due to sparse randomized controlled trials. More high-quality, prospective studies with sufficient control of confounding factors and repeated HbA1c measures are necessary.
