Fine Needle Aspiration Cytology of Osteoclast-like Giant Cell Tumor of the Liver: A Case Report.
- Author:
Chan Sik PARK
1
;
Ji Eun KIM
;
Mee Soo CHANG
Author Information
1. Department of Pathology, Seoul National University, College of Medicine, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Osteoclast-like giant cell tumor;
Liver;
Fine needle aspiration cytology
- MeSH:
Abdominal Wall;
Biopsy, Fine-Needle*;
Biopsy, Needle;
Chromatin;
Cytoplasm;
Female;
Giant Cell Tumors*;
Giant Cells*;
Humans;
Keratins;
Liver*;
Middle Aged;
Prognosis;
Vimentin
- From:Korean Journal of Cytopathology
1999;10(1):79-84
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Osteoclast-like giant cell tumor of the liver is an extremely rare malignancy with poor prognosis. To our knowledge, 5 cases have been reported in English literatures, but there was no report about fine needle aspiration cytologic(FNAC) features. We experienced a case of osteoclast-like giant cell tumor of the liver obtained by computed tomography(CT)-guided FNAC and needle biopsy. The cytologic findings mimicked giant cell tumor of the bone. A large hepatic mass of the left lobe with abdominal wall invasion was found by CT in a 46-year-old female complaining of epigastric pain. The FNAC showed moderately cellular smears consisting of osteoclast-like giant cells and mononuclear cells, which were individually scattered or intermingled in clusters. The osteoclast-like giant cells had abundant cytoplasms and multiple small round nuclei with fine chromatin and distinct nucleoli. The mononuclear cells had moderate amount of cytoplasm and relatively bland-looking oval nuclei with single small nucleoli. All of the cytologic features recapitulated the histologic findings of bland-looking osteoclast-like multinucleated giant cells evenly dispersed throughout the background of mononuclear cell. The immunohistochemical study showed positive reaction for CD68 and vimentin, but negative for cytokeratin in both osteoclast-like giant cells and mononuclear cells.
