Usefulness of E-Cadherin Expression in Malignant Effusion .
- Author:
Sung Jig LIM
1
;
Gou Young KIM
;
Youn Wha KIM
;
Yong Koo PARK
;
Juhie LEE
;
Moon Ho YANG
;
Nam Hee WON
Author Information
1. Department of Pathology, College of Medicine, Kyung Hee University, , Seoul, Korea. Leejuhie@chollian.net
- Publication Type:Original Article
- Keywords:
E-cadherin;
Body fluids;
Carcinoma;
Reactive mesothelial cells;
Immunocytochemistry
- MeSH:
Adenocarcinoma;
Body Fluids;
Cadherins*;
Immunohistochemistry;
Sensitivity and Specificity
- From:Korean Journal of Cytopathology
1999;10(2):121-126
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The usefulness of E-cadherin immunostaining as a marker of malignancy in the body fluids was investigated in the present study. Thirty-three histologically proven cases of cell blocks from the pleural, peritoneal, and pericardial fluids were studied by immunocytochemistry for E-cadherin antibody using LSAB method. These cases were cytologically diagnosed as adenocarcinoma (25 cases) and atypical cells (8 cases). Tumor cells showed strong positive membranous staining for E-cadherin antibody in 21 out of 25 cases (84%) of adenocarcinoma. E-cadherin staining was not found in 6 of 8 cases of suspicious maligancy. The sensitivity and specificity were 84% and 75%, respectively. Reactive mesothelial cells and inflammatory cells scattered were all negative. In conclusion, E-cadherin is an useful adjunctive marker to distinguish reactive mesothelial cells from the carcinoma cells in the body fluids.
