The Usefulness of Concomitant High-Risk Human Papillomavirus Test and Colposcopy in Combination with the Papanicolaou Test in ASCUS Patients.
- Author:
Min Kyung KIM
1
;
Jin Hee SOHN
;
Chul Hwan KIM
;
Jong Sang CHOI
Author Information
1. Department of Pathology, Kangbuk Samsung Hospital, College of Medicine, Sungkyunkwan University, Korea. mkgene.kim@samsung.com
- Publication Type:Original Article
- Keywords:
Human papillomavirus;
ASCUS;
Colposcopy
- MeSH:
Biopsy;
Colposcopy*;
Diagnosis;
Follow-Up Studies;
Humans*;
Hysterectomy;
Mass Screening;
Papanicolaou Test*;
Sensitivity and Specificity;
Triage
- From:Korean Journal of Cytopathology
2005;16(1):18-24
- CountryRepublic of Korea
- Language:English
-
Abstract:
The objective of this study was to ascertain whether or not the high-risk human papillomavirus(HPV) test, when coupled with Papanicolaou(Pap) smears, would prove useful in the screening and management of patients in whom abnormal Pap smear results had been obtained. Concomitant high-risk HPV detection using the hybrid capture II test and colposcopy with a Pap smear were performed with 176 patients, all of whom had been screened for both cervical carcinoma and precancerous lesions. We concomitantly performed colposcopies on these patients. Upon the follow-ups, the histologic diagnoses of these patients were confirmed via either biopsy or hysterectomy. The rate of high-risk HPV detection was correlated with cytologic diagnoses and colposcopic findings. The group composed of the high-risk HPV-positive ASCUS patients exhibited a 55.7% rate of cervical intraepithelial neoplasia(CIN), a significantly higher rate than the 7.5% result obtained in the high-risk HPV- negative ASCUS group. HPV test showed high sensitivity(87%) and low specificity (62.6%) in detection of CIN and colposcopy also showed high sensitivity (88%) and low specificity(22%). Any combination of these tests improve sensitivity, but not specificity. High-risk HPV tests, when coupled with Pap smears, constituted a useful triage approach with regard to colposcopy-directed biopsies in patients in whom a cytologic diagnosis of ASCUS had been rendered.
