Plasma Cell Granuloma in Cyclosporine-Induced Gingival Overgrowth: A Report of Two Cases with Immunohistochemical Positivity of Interleukin-6 and Phospholipase C-gamma1.
10.3346/jkms.2002.17.5.704
- Author:
Sung Sook KIM
1
;
Dae Woon EOM
;
Joo Ryung HUH
;
Iel Yong SUNG
;
In Pyo CHOI
;
Sung Ho RYU
;
Pann Ghill SUH
;
Sung Min CHUNG
Author Information
1. Department of Pathology, Medical School, University of Ulsan, Ulsan, Korea. sungmin@mm.ewha.ac.kr
- Publication Type:Case Report
- Keywords:
Cycosporin;
Side Effect;
Gingival Overgrowth;
Plasma Cells;
Interleukin-6;
Phospholipase C
- MeSH:
Cyclosporine/adverse effects;
Female;
Gingival Diseases/*chemically induced/enzymology/immunology/pathology;
Granuloma, Plasma Cell/*chemically induced/enzymology/immunology/pathology;
Humans;
Immunohistochemistry;
Immunosuppressive Agents/adverse effects;
Interleukin-6/metabolism;
Kidney Transplantation;
Male;
Middle Aged;
Phospholipase C gamma;
Type C Phospholipases/metabolism
- From:Journal of Korean Medical Science
2002;17(5):704-707
- CountryRepublic of Korea
- Language:English
-
Abstract:
We report two cases of gingival plasma cell granuloma in a 34-yr-old and 40-yr-old two male renal transplant recipients with cyclosporine A (CsA)-induced gingival overgrowth (GO). Histologically, these lesions were composed of mature plasma cells, showing polyclonality for both lambda and kappa light chains and fibrovascular connective tissue stroma. In addition to the fact that CsA-induced plasma cell granuloma is rare, the salient features of our cases were the secretion of interleukin-6 and overexpression of phospholipase C-gamma1 of the tumor cells, which may explain the mechanisms of CsA- induced GO.
