Cytologic Features of Endodermal Sinus Tumor of Ovary in the Ascitic Fluid: Report of a Cases.
- Author:
Eun Sun JEONG
1
;
Young Shin KIM
;
Chang Suk KANG
;
Sang In SHIM
Author Information
1. Department of Clinical Pathology, Catholic University Medical college, Korea.
- Publication Type:Case Report
- Keywords:
Endodermal sinus tumor;
Ascites
- MeSH:
alpha-Fetoproteins;
Ascites;
Ascitic Fluid*;
Cytoplasm;
Diagnosis;
Endoderm*;
Endodermal Sinus Tumor*;
Female;
Hyalin;
Ovary*
- From:Korean Journal of Cytopathology
1995;6(2):204-208
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The cytologic findings of endodermal sinus tumor of the ovary are reported. The cytologic preperations were obtained from ascitic specimens. The findings on Papanicolaou-stained smears included a clean background and poorly preserved atypical cells loosely arranged in irregular or papillary groups. At high magnification, the cells had ill-defined and microvacuolated cytoplasms, with an increased nuclear-cytoplasmic ratio and prominent nucleoli. Hyaline globules characteristic of the alpha-fetoprotein (AFP)-synthesizing cells of endodermal sinus tumor were observed within the cells with periodic-acid-Schiff (PAS) stain. The presence of PAS - positive hyaline globules can be regarded, therefore, as a diagnostic clue to endodermal sinus tumor in an appropriate clinical setting and in the presence of AFP production. The cytologic findings in a cell block is important, in addition to smears, to obtain more diagnostic clues. A preliminary cytomorphologic diagnosis of this highly malignant tumor is valuable as a guide in planning further immunocytochemical and serologic studies.
