Cytologic Features of Medullary Carcinoma of the Thyroid Occurring in a Child: A Case Report.
- Author:
Jeong Seok MOON
1
;
Hye Sun KIM
;
Seong Jin CHO
;
Yang Seok CHAE
;
Bom Woo YEOM
Author Information
1. Department of Pathology, Korea University College of Medicine, Korea.
- Publication Type:Case Report
- Keywords:
Medullary carcinoma;
Thyroid gland;
Child;
Cytopathologic findings
- MeSH:
Amyloid;
Calcitonin;
Carcinoma, Medullary*;
Child*;
Chromatin;
Cytoplasm;
Female;
Humans;
Intranuclear Inclusion Bodies;
Neck;
Neuroendocrine Tumors;
Thyroid Gland*
- From:Korean Journal of Cytopathology
1996;7(2):213-217
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Medullary carcinoma of the thyroid gland is a malignant neuroendocrine tumor arising from calcitonin producing-parafollicular cells. The tumor is clinically divided into sporadic and familial form, constituting about 80% and 20%, respectively. Recently, we experienced a case of unilateral and solitary sporadic medullary carcinoma of the left thyroid gland. The patient was a 9 year-old female, who presented with a palpable mass on the anterior lateral neck of 8 months duration without any familial and personal history of neuroendocrine disease. The cytopathologic findings showed spindle cells and plasmacytoid cells in the background of colloid-like materal. The nuclei were eccentrically located, mildly hyperchromatic and pleomorphic, showing speckled chromatin pattern without nuclear inclusion or prominent nucleoli. The cytoplasm was abundant and had a pale granular cyanophilic appearance. No amyloid materal could be identified.
