A case of autoimmune hemolytic anemia due to autoanti-Ce.
- Author:
Oh Hun KWON
;
Hyun Ok KIM
;
Sung Ran CHO
;
Kil Young KIM
;
Kyung A LEE
;
Dong Eun YONG
;
Moon Jung KIM
- Publication Type:Case Report
- MeSH:
Anemia;
Anemia, Hemolytic, Autoimmune*;
Antibodies;
Autoantibodies;
Blood Group Incompatibility;
Blood Transfusion;
Child;
Coombs Test;
Female;
Hemolysis;
Histiocytosis, Langerhans-Cell;
Humans;
Mothers;
Sensitivity and Specificity
- From:Korean Journal of Blood Transfusion
1996;7(2):257-261
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
A 12-year-old female with histiocytosis X accompanied by autoimmune hemolytic anemia. During the episode of hemolysis, the hemoglobin level fell to 5.2 g/dL. The direct antiglobulin test was weakly positive. The anti-C and anti-e were identified in her serum. The Rh subgroup of her family(father, mother and brother) including the patient, were all same as DCe. The antibodies which showed anti-C and anti-e specificity were confirmed autoanti-Ce(non-separable) using the serum absorbed with various known Rh phenotyped RBCs. Two packed RBCs phenotyped as DeE were transfused for correction of anemia. Acute and delayed hemolytic transfusion reactions were not noted after transfusion. Identification of blood group specific autoantibodies may be benificial in such case for blood transfusion.
