Effect of Chloral Hydrate on Sedation and Arterial Oxygen Saturation in Children with Congenital Heart Disease.
10.4097/kjae.1996.31.6.713
- Author:
Myung Won CHO
1
;
Jae Wan KIM
Author Information
1. Department of Anesthesiology, Ulsan University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Heart congenital defect;
Hypnotics chloral hydrate;
Oxygen saturation;
Premedication
- MeSH:
Airway Obstruction;
Child*;
Chloral Hydrate*;
Heart;
Heart Defects, Congenital*;
Humans;
Hypnotics and Sedatives;
Oxygen*;
Premedication;
Thoracic Surgery
- From:Korean Journal of Anesthesiology
1996;31(6):713-719
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: To study the effect of chloral hydrate oral premedication on sedation and arterial oxygen saturation in noncyanotic and cyanotic congenital heart disease children. METHODS: 18 noncyanotic congenital heart disease patients and 18 cyanotic congenital heart disease patients scheduled for cardiac surgery were premedicated orally with chloral hydrate 50 mg/kg. Arterial oxygen saturations were measured with pulse oximeter before and after oral premedication and sedation effects evaluated. RESULTS: In noncyanotic group oxygen saturation decreased from 98.7+/-0.95% (mean+/-?SD) before premedication to 97.8+/-1.15% after premedication with statistical significance but without meaning. 16 of the 18 patients (89%) were adequately sedated without airway obstructions. In cyanotic group oxygen saturation increased with statistical insignificance from 73.5+/-10.9% before premedication to 74.0+/-13.9% after premedication. 15 of the 18 patients(83%) were adequately sedated. Effects on oxygen saturation in cyanotic group patients were quite variable with 3 of the patients revealing more than 10% decrease in oxygen saturation. CONCLUSIONS: Chloral hydrate has a good sedative effects on congenital heart disease children but its effects on oxygen saturation were variable and close monitoring followed by oxygen administration is recommended in cyanotic heart patients.
