Prognostic Value of Angiogenesis in Breast Cancer.
- Author:
Jong Hyeon KIM
1
;
Dae Sung YOON
;
Chan Heun PARK
;
Jae Jung LEE
;
Chul Jae PARK
;
Eun Sook NAM
;
Hyung Sick SIN
Author Information
1. Departments of Surgery, Kang Dong Sacred Heart Hospital, Hallym University Medical College.
- Publication Type:Original Article
- Keywords:
Angiogenesis;
Breast cancer
- MeSH:
Breast Neoplasms*;
Breast*;
Carcinoma, Ductal;
Endothelial Cells;
Estrogens;
Follow-Up Studies;
Humans;
Microscopy;
Microvessels;
Noma;
Prognosis
- From:Journal of the Korean Surgical Society
1998;55(5):653-661
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: There is considerable experimental evidence to indicate that tumor growth is dependent on angiogenesis. To investigate how tumor angiogenesis correlates with clinical factors and prognosis in breast carcinoma, we counted microvessels (capillaries and venules) and graded the density of micro vessels within the invasive ductal carcinomas of 59 patients. METHODS: Using light microscopy, we highlighted the vessels by staining their endothelial cells immu nohistochemically for rabbit antihuman factor-VIII related antigen (Dako L1809, USA). The microvessels were carefully counted (per 200 field) in the most active areas of neovascularization without knowledge of either the outcome in the patient or the clinical variables. RESULTS: The mean age was 47.8 years. There was no statistical correlation between angiogenesis and either estrogen receptor status or age. However, there was a statistical correlation with tumor size (p< or =0.05). There was a statistical difference between lymph-node-metastasis positive group and negative group (p= 0.006). Angiogenesis correlated statistically with TMN stage (microvessels count:stage I= 31.27, stage II= 40.74, and stage III= 78.9)(p= 0.001). There was a statistical correction between angiogenesis and follow-up results (microvessels counts:disease free group= 42.11, living metastatic group= 63.64, and expired group= 73.60)(p= 0.031). CONCLUSIONS: In this study, the degree of angiogenesis (the number of microvessels per 200 field in the area of most intensive neovascularization) may have a predictive value in invasive breast carci nomas. Therefore, assessment of tumor angiogenesis may give us useful information for selecting thera peutic and follow-up plan for patients with breast carcinomas.
