VEGF and Ki-67 Overexpression in Predicting Poor Overall Survival in Adenoid Cystic Carcinoma.
- Author:
Seongyeol PARK
1
;
Soo Jeong NAM
;
Bhumsuk KEAM
;
Tae Min KIM
;
Yoon Kyung JEON
;
Se Hoon LEE
;
J Hun HAH
;
Tack Kyun KWON
;
Dong Wan KIM
;
Myung Whun SUNG
;
Dae Seog HEO
;
Yung Jue BANG
Author Information
- Publication Type:Original Article
- Keywords: Adenoid cystic carcinoma; Immunohistochemistry; Vascular endothelial growth factor; Ki-67; Prognosis
- MeSH: Adenoids*; Carcinoma, Adenoid Cystic*; Disease-Free Survival; Fibroblast Growth Factor 2; Humans; Immunohistochemistry; Medical Records; Multivariate Analysis; Nasal Cavity; Prognosis; Proto-Oncogenes; Receptors, Fibroblast Growth Factor; Receptors, Platelet-Derived Growth Factor; Risk Factors; Vascular Endothelial Growth Factor A*
- From:Cancer Research and Treatment 2016;48(2):518-526
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: The purpose of this study was to evaluate potential prognostic factors in patients with adenoid cystic carcinoma (ACC). MATERIALS AND METHODS: A total of 68 patients who underwent curative surgery and had available tissue were enrolled in this study. Their medical records and pathologic slides were reviewed and immunohistochemistry for basic fibroblast growth factor, fibroblast growth factor receptor (FGFR) 2, FGFR3, c-kit, Myb proto-oncogene protein, platelet-derived growth factor receptor beta, vascular endothelial growth factor (VEGF), and Ki-67 was performed. Univariate and multivariate analysis was performed for determination of disease-free survival (DFS) and overall survival (OS). RESULTS: In univariate analyses, primary site of nasal cavity and paranasal sinus (p=0.022) and Ki-67 expression of more than 7% (p=0.001) were statistically significant factors for poor DFS. Regarding OS, perineural invasion (p=0.032), high expression of VEGF (p=0.033), and high expression of Ki-67 (p=0.007) were poor prognostic factors. In multivariate analyses, primary site of nasal cavity and paranasal sinus (p=0.028) and high expression of Ki-67 (p=0.004) were independent risk factors for poor DFS, and high expression of VEGF (p=0.011) and Ki-67 (p=0.011) showed independent association with poor OS. CONCLUSION: High expression of VEGF and Ki-67 were independent poor prognostic factors for OS in ACC.
