A Case of Drug Rash with Eosinophilia and Systemic Symptoms Associated with Valproic Acid and Olanzapine Treatment in Patient with Bipolar Disorder.
- Author:
Ung LEE
1
;
Se Won LIM
Author Information
1. Department of Psychiatry, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea. knappe@paran.com
- Publication Type:Case Report
- Keywords:
Valproic acid;
Olanzapine;
Exanthema;
Hypersensitivity
- MeSH:
Anticonvulsants;
Bipolar Disorder*;
Carbamazepine;
Drug Hypersensitivity Syndrome;
Eosinophilia*;
Exanthema*;
Fever;
Humans;
Hypersensitivity;
Leukocytosis;
Lymphocytosis;
Male;
Sulfonamides;
Valproic Acid*
- From:Journal of the Korean Society of Biological Psychiatry
2017;24(3):162-166
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome is a potentially life-threatening, medication-induced hypersensitivity reaction with long latency. It is characterized by fever, rash, leukocytosis with eosinophilia, atypical lymphocytosis, and internal organ involvement. The most common causes of DRESS syndrome are sulfonamides and anticonvulsants such as carbamazepine and lamotrigine. However, valproic acid and olanzapine could develop DRESS syndrome. We report a case of DRESS syndrome associated with valproic acid and olanzapine in a 41 years old male patient with bipolar disorder.
