R347C Polymorphisms in ADRA1A Genes and Mirtazapine Treatment Response in Koreans with Major Depression.
- Author:
Jahyun KOO
1
;
Min Soo LEE
;
Byungju HAM
;
Eun Soo WON
Author Information
1. Department of Psychiatry, College of Medicine, Korea University, Seoul, Korea. leeminso@korea.ac.kr
- Publication Type:Original Article
- Keywords:
Major depressive disorder;
Adrenoreceptor alpha 1a;
ADRA1A R347C;
Mirtazapine;
Treatment response
- MeSH:
Alleles;
Depression*;
Depressive Disorder, Major;
Genotype;
Homozygote;
Humans;
Polymorphism, Genetic;
Serotonergic Neurons
- From:Journal of the Korean Society of Biological Psychiatry
2015;22(4):179-186
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: Adrenergic alpha 1 and 2 receptors work as pathways to control the serotonergic neuron moderation and mirtazapine acts as antagonist of these receptors. The adrenoreceptor alpha 1a (ADRA1A) gene, which encodes adrenergic alpha 1 receptor, has Arg347Cys genetic polymorphism and the polymorphism has strong relationship with many neuro-psychiatric diseases. In this study, we explored the relationship between ADRA1A R347C polymorphism and mirtazapine treatment response in Koreans with major depression. METHODS: 352 patients enrolled in this study, and the symptoms were evaluated by 17-item Hamilton Depression Rating (HAMD-17) scale. After 1, 2, 4, 8, and 12 weeks of mirtazapine treatment, the association between ADRA1A R347C polymorphism and remission/response outcomes was evaluated. RESULTS: Treatment response to mirtazapine was significantly better in T allele carriers than C allele homozygotes after 12 weeks of mirtazapine monotherapy. The percentile decline of HAMD-17 score in T allele carriers was larger than that of C allele homozygotes. ADRA1A R347C genotypes were not significantly associated with remission. CONCLUSIONS: The result showed that treatment response to mirtazapine was significantly associated with ADRA1A R347C genetic polymorphism. T allele carriers showed better treatment response than C allele homozygotes. It can be supposed that T allele carriers have a trend of better treatment response to mirtazapine monotherapy.
