Role of p11 (S100A10) in Depression and Antidepressant Effects.
- Author:
Sung Woo PARK
1
;
Mi Kyong SEO
;
Jung Goo LEE
;
Young Hoon KIM
Author Information
1. Paik Institute for Clinical Research, Inje University College of Medicine, Busan, Korea. neuro109@hanmail.net
- Publication Type:Original Article
- Keywords:
p11;
Depression;
Antidepressant;
Antidepressant effects
- MeSH:
Depression*;
Humans;
Rodentia;
Up-Regulation
- From:Journal of the Korean Society of Biological Psychiatry
2016;23(1):24-28
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
p11 protein (S100A10) is downregulated in depressive-like states of human and rodent. Antidepressant drug treatment increases p11 levels in rodent models. We reviewed studies demonstrating that p11 levels are regulated in depression and by antidepressant treatment and that p11 upregulation exerts antidepressant effects. Current studies on p11 underscore the importance of p11 as a potential antidepressant target.
