Relationship between White Matter Changes and Cognitive Dysfunction in the Elderly with Subjective Memory Complaint.
- Author:
Eun Young SHIN
1
;
Han Yong JUNG
;
Yang Rae KIM
;
Soyoung Irene LEE
;
Shin Gyeom KIM
Author Information
1. Department of Psychiatry, Soonchunhyang University Hospital, Bucheon, Korea. hanyjung@schbc.ac.kr
- Publication Type:Original Article
- Keywords:
White matter changes;
Executive function;
Cognition;
Risk factor
- MeSH:
Aged;
Cholesterol;
Cognition;
Dementia;
Executive Function;
Heart Diseases;
Humans;
Hyperlipidemias;
Hypertension;
Memory;
Memory, Short-Term;
Neuropsychological Tests;
Pyridines;
Risk Factors;
Thiazoles
- From:Journal of the Korean Society of Biological Psychiatry
2011;18(3):141-147
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: The purpose of this study is to evaluate the relationship between the severity of white matter changes (WMC), risk factors and cognitive domains, including executive function profiles. METHOD: Forty nine subjects over 55 years with subjective memory complaints were assessed with MRI and neuropsychological tests. The WMC were assessed by MRI T2-FLAIR images and divided into 3 groups of mild vs. moderate vs. severe and 2 groups of mild-moderate vs. severe by using Mantyla's criteria and Fazeka's criteria. The risk factors were examined in hypertension, heart disease history and chemistry Lab. Medical conditions which affect to cognitive dysfunction and definite dementia were also excluded. RESULTS: Comparing 3 groups, hypertension was identified as a risk factor of the WMC. Comparing 2 groups, total cholesterol and LDL were identified for as the risk factor of WMC. The severity of WMC was significantly associated with cognitive disturbances and their main effect on cognition was working memory and inhibition. CONCLUSION: The risk factors of the WMC in the elderly were hypertension, hyperlipidemia. The severity of WMC appears to be associated with executive dysfunction in the elderly.
