Venlafaxine-Induced Acute Toxic Hepatitis.
- Author:
Kyeong Sae NA
1
;
Heesung HWANG
;
Shin Gyeom KIM
;
Soyoung Irene LEE
;
Han Yong JUNG
Author Information
1. Department of psychiatry, College of Medicine, Soonchunhyang University Bucheon Hospital, Bucheon, Korea. hanyjung@schmc.ac.kr
- Publication Type:Case Report
- Keywords:
Venlafaxine;
Drug-induced liver injury;
Antidepressant;
Drug toxicity
- MeSH:
Alanine Transaminase;
Antidepressive Agents;
Aspartate Aminotransferases;
Biopsy;
Cyclohexanols;
Cytochrome P-450 Enzyme System;
Drug Toxicity;
Drug-Induced Liver Injury;
Female;
Humans;
Liver;
Middle Aged;
Somatoform Disorders;
Desvenlafaxine Succinate;
Venlafaxine Hydrochloride
- From:Journal of the Korean Society of Biological Psychiatry
2011;18(3):159-162
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Venlafaxine is among the most widely prescribed antidepressants. It is extensively metabolized to O-desmethylvenlafaxine via cytochrome P450 (CYP) 2D6. We report a case of acute toxic hepatitis resulting from venlafaxine in a 54-year-old woman with pain disorder. During venlafaxine treatment, laboratory tests revealed elevated liver enzymes with a maximum of 169 IU/L for aspartate transaminase (AST) and 166 IU/L for alanine transaminase (ALT). AST and ALT levels returned to normal after 6 days of discontinuation of venlafaxine. The patient was finally diagnosed with acute toxic hepatitis through liver biopsy. This case indicates the importance that clinicians should be aware of the hepatotoxicity of venlafaxine in practice.
