A Voxel-Based Morphometry of Gray Matter Volume Reduction in Patients with Mild Cognitive Impairment.
- Author:
Boeun YOO
1
;
Changtae HAHN
;
Chang Uk LEE
;
Seung Chul HONG
;
Hyun Kook LIM
Author Information
1. Department of Psychiatry, St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
MCI;
Optimized VBM;
Volumetry
- MeSH:
Alzheimer Disease;
Antineoplastic Combined Chemotherapy Protocols;
Bleomycin;
Brain;
Cognition;
Hippocampus;
Humans;
Methotrexate;
Mild Cognitive Impairment;
Parietal Lobe;
Prognosis;
Temporal Lobe;
Vincristine
- From:Journal of the Korean Society of Biological Psychiatry
2011;18(4):232-238
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: Optimized voxel based morphometry (VBM) has been increasingly applied to investigate differences in the brain morphology between a group of patients with mild cognitive impairment (MCI) and control subjects. Optimized VBM permits comparison of gray matter (GM) volume at voxel-level from the entire brain. The purpose of this study was to assess the regional GM volume change measured by optimized VBM in MCI subjects compared to controls. METHODS: Twenty patients with MCI and 20 control subjects with normal cognition were recruited for this study. We applied the optimized VBM protocol to the image data including study-specific template and the modulation of the data with the Jacobian determinants. GM volume differences between the MCI subjects and the control subjects and their correlations with the neuropsychological performances were investigated. RESULTS: Optimized VBM analysis revealed GM volume reduction in hippocampus, precentral gyrus, insula and parietal operculum in the MCI group compared to the control group (family wise error corrected p < 0.05). Korean version of the Consortium to Establish a Registry for Alzheimer's disease (CERAD-K) word list recall scores were significantly correlated with the GM volumes of hippocampus, precuneus and posterior cingulate in the MCI group (FWE corrected p < 0.05). CONCLUSIONS: The results confirm previous findings of atrophic changes in medial temporal lobe and parietal lobe in the MCI group and suggest that these abnormalities may be related with cognitive decline and prognosis in patients with MCI.
