Right Caudate Volumetric Differences in Young Healthy Adults with Different Dopamine DRD2/ANKK1 Taq 1a Polymorphisms.
- Author:
Yujin JEON
1
;
Yera CHOI
;
Jihyun H KIM
;
Jiyoung J JUNG
;
Dajung J KIM
;
Sukgyeong YU
;
Jooyeon Jamie IM
;
Junghyun H LEE
Author Information
1. Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea. junghyunlee@snu.ac.kr
- Publication Type:Original Article
- Keywords:
DRD2/ANKK1 Taq 1a polymorphism;
Caudate;
Brief psychiatric rating scale;
Magnetic resonance imaging
- MeSH:
Adult;
Alleles;
Brain;
Brief Psychiatric Rating Scale;
Dopamine;
Homozygote;
Humans;
Magnetic Resonance Imaging;
Magnetic Resonance Spectroscopy;
Phosphotransferases
- From:Journal of the Korean Society of Biological Psychiatry
2011;18(4):254-259
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: The aim of this study was to assess variations in caudate volume according to dopamin receptor D2/ankyin repeat and kinase domain containing 1 (DRD2/ANKK1) Taq 1a polymorphisms in young healthy adults and to evaluate the relationship between caudate volumes and psychiatric symptoms as measured by the Brief Psychiatric Rating Scale. METHODS: Genetic information regarding DRD2/ANKK1 Taq 1a and T1-weighted brain magnetic resonance images were acquired from 30 young healthy adults. Automatic segmentation of caudate was performed using the FreeSurfer program. RESULTS: Individuals with A2 homozygotes of DRD2/ANKK1 Taq 1a polymorphisms (n = 10) had greater right caudate volumes compared to those with A1 allele (s)(18.4% greater ; p = 0.019). Right caudate volumes were negatively associated with total scores of the Brief Psychiatric Rating Scale (beta=-0.50 ; p = 0.016). CONCLUSIONS: Our findings suggest the possibility that DRD2/ANKK1 Taq 1a polymorphisms may underlie the psychiatric symptoms by influencing the structure of the right caudate.
