Comorbidity of Posttraumatic Stress Disorder and Its Effect on Treatment Outcomes in Patients with Schizophrenia : One-Year Prospective Follow-Up Study.
- Author:
Sung Jong PARK
1
;
Nam Hee KIM
;
Jae Yeol JEONG
;
Sunny LEE
Author Information
1. Department of Psychiatry, Seoul Metropolitan Eunpyeong Hospital, Seoul, Korea. nadianam@gmail.com
- Publication Type:Original Article
- Keywords:
Schizophrenia;
Posttraumatic stress disorder;
Trauma;
Prevalence;
Outcome
- MeSH:
Comorbidity;
Follow-Up Studies;
Humans;
Prevalence;
Prospective Studies;
Psychotic Disorders;
Schizophrenia;
Stress Disorders, Post-Traumatic;
Treatment Outcome
- From:Journal of the Korean Society of Biological Psychiatry
2009;16(4):256-265
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: The aims of this study were to assess a) the prevalence of trauma and posttraumatic stress disorder(PTSD) in schizophrenic patients and b) the differences in symptomatology and outcome after 1year treatment between those with and without PTSD. METHODS: Twenty eight schizophrenia and schizoaffective disorder patients completed the Positive and Negative Syndrome Scale(PANSS), Life Stressor Checklist-Revised(LSCL-R), Clinician-Administered PTSD Scale (CAPS), Dissociative Experiences Scale(DES), Hamilton Psychiatry Rating Scale for Depression(HAM-D), and Rosenberg Self-Esteem Scale(RSE). RESULTS: Twenty six patients(92.9%) had at least one trauma in their life time. Eleven patients(39.3%) were diagnosed with PTSD. PTSD group had significantly higher scores on HAM-D and DES but lower scores on RSE. PTSD group also had significantly lower score in the baseline PANSS Negative score. Higher CAPS scores were significantly correlated with lower baseline PANSS Negative score and greater change after 1year of PANSS Negative score. CONCLUSION: These results showed that the prevalences of trauma and PTSD are high in schizophrenic patients and suggested that PTSD and trauma-related symptoms affected the symptomatology and treatment outcome. More research is warranted to better understand the effects of PTSD in schizophrenic patients.
