Comparative Study on Initial Symptoms Using Single Photon Emission Computer Tomography in Schizophrenia.
- Author:
Jin Gu LEE
1
;
Seong Min KIM
;
Young Duk SEO
;
Ki Seong KIM
;
Seong Keun WANG
;
Ik Seung CHEE
;
Jeong Lan KIM
Author Information
1. Department of Psychiatry, School of Medicine, Chungnam National University, Daejeon, Korea. kimjl@cnu.ac.kr
- Publication Type:Comparative Study ; Original Article
- Keywords:
(99m)Tc-ECD SPECT;
Brain;
Hallucination;
Delusion;
Schizophrenia;
Perfusion
- MeSH:
Brain;
Delusions;
Frontal Lobe;
Hallucinations;
Humans;
Parietal Lobe;
Perfusion;
Schizophrenia;
Temporal Lobe;
Thinking;
Tomography, Emission-Computed, Single-Photon
- From:Journal of the Korean Society of Biological Psychiatry
2010;17(3):127-135
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: This study was conducted to compare between hallucination group and delusion group in patient with schizophrenia, using Brain (99m)Tc-ECD SPECT. METHODS: Among 16 patients with less than 3 schizophrenic episodes, 8 patients whose initial symptom was hallucination were assigned to the hallucination group, and other 8 patients with initial sumptom of delusion were assinged to the hallucination group. All of the patients clinically evaluated using the PANSS and BPRS. Both groups of patients and 8 healthy subjects underwent (99m)Tc-ECD SPECT. RESULTS: Score of thinking disturbance subscale of BPRS were significantly lower in the hallucination group than the delusion group. In SPECT analysis, the hallucination group showed significantly increased perfusion in some areas of the right temporal lobe, bilateral limbic lobes and left parietal lobe compared to delusion group. Both group had a reduced rCBF in some areas of the frontal lobe. CONCLUSION: The hallucniation group, compared with the delusion group, showed significantly increased regional cerebral blood flow in some regions. Therefore, this data suggests that different neural substrates may affect the process of auditory hallucination and delusion.
