Radiation-Induced Sarcoma: A 15-Year Experience in a Single Large Tertiary Referral Center.
- Author:
Kyung Su KIM
1
;
Ji Hyun CHANG
;
Noorie CHOI
;
Han Soo KIM
;
Ilkyu HAN
;
Kyung Chul MOON
;
Il Han KIM
;
Hak Jae KIM
Author Information
- Publication Type:Original Article
- Keywords: Radiation-induced neoplasms; Sarcoma; Survival
- MeSH: Diagnosis; Follow-Up Studies; Humans; Incidence; Korea; Multivariate Analysis; Neoplasms, Radiation-Induced; Osteosarcoma; Retrospective Studies; Sarcoma*; Survival Rate; Tertiary Care Centers*
- From:Cancer Research and Treatment 2016;48(2):650-657
- CountryRepublic of Korea
- Language:English
- Abstract: PURPOSE: The purpose of this study is to report on the incidence and the experience in management of radiation-induced sarcoma (RIS) at a large single center in Korea for 15 years. MATERIALS AND METHODS: We retrospectively reviewed the sarcoma registry of a large institution from January 2000 to April 2014. RESULTS: Out of the 3,674 patients listed in the registry, 33 patients (0.9%) diagnosed with RIS were identified. The median latency of RIS was 12.1 years. The number of cases of RIS increased from four cases in the years 2000-2003 to 14 cases in the years 2012-2014. The most common histology was osteosarcoma (36.4%). The median follow-up period was 23.1 months, the median overall survival (OS) of all patients was 2.9 years, and their 5-year survival rate was 44.7%. Univariate and multivariate analyses showed association of the age at diagnosis (p=0.01) and the treatment aim (p=0.001) with the OS. The median OS and the 5-year survival rate of patients treated with curative surgery (n=19) were 9.6 years and 65%, respectively, and of the conservatively treated patients, 0.7 years and 0% (n=14). Re-irradiation was delivered to nine patients, and radiation toxicity was observed in five patients. CONCLUSION: In this study, RIS accounted for 0.9% of the cases of sarcoma, with increasing incidence. Despite the association of curative resection with increased survival, it could be applied to only 58% of the patients. Considering the limited treatment options for RIS, conduct of a genetic study to identify the underlying mechanism of RIS is needed.
