Contribution of Genetic and Neuroimaging Studies towards a Better Understanding of Post-Traumatic Stress Disorder.
- Author:
Jieun E KIM
1
;
In Kyoon LYOO
;
Chansoo JUN
;
Yu Sang LEE
Author Information
1. Department of Psychiatry, Seoul National University College of Medicine, Seoul, Korea.
- Publication Type:Review
- Keywords:
PTSD;
Genetics;
Neuroimaging
- MeSH:
Amygdala;
Axis, Cervical Vertebra;
Brain-Derived Neurotrophic Factor;
Dopamine;
Epigenomics;
Genome-Wide Association Study;
Hippocampus;
Neuroimaging;
Norepinephrine;
Prefrontal Cortex;
Proteins;
Serotonin;
Stress Disorders, Post-Traumatic;
Tacrolimus Binding Proteins
- From:Journal of the Korean Society of Biological Psychiatry
2010;17(4):177-193
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
significant advances have been made in understanding the biological underpinnings of post-traumatic stress disorder(PTSD), particularly in the field of genetics and neuroimaging. Association studies in candidate genes related with hypothalamic-pituitary-adrenal axis, monoamines including serotonin, dopamine and noradrenaline, and proteins including FK506-binding protein 5 and brain-derived neurotrophic factor have provided important insights with regard to the vulnerability factors in PTSD. Genome-wide association studies and epigenetic studies may provide further information for the role of genes in the pathophysiology of PTSD. Hippocampus, medial prefrontal cortex, anterior cingulated cortex and amygdala have been considered as key structures that underlie PTSD pathophysiology. Future research that combines genetic and neuroimaging information may provide an opportunity for a more comprehensive understanding of PTSD.
