Association of the 5-HT5A Receptor Gene Polymorphisms and Citalopram Response in Korean Patients with Major Depressive Disorder.
- Author:
Jin Hyun SHIM
1
;
Jong Woo PAIK
;
Jeung Woong OH
;
Rhee Hun KANG
;
Hwa Young LEE
;
Min Soo LEE
Author Information
1. Apple-tree Psychiatric Clinic, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Depression;
5HT5A receptor;
Polymorphism;
Citalopram;
Pharmacogenetics
- MeSH:
Citalopram;
Depression;
Depressive Disorder, Major;
Genotype;
Humans;
Pharmacogenetics;
Polymerase Chain Reaction;
Polymorphism, Genetic;
Receptors, Serotonin
- From:Journal of the Korean Society of Biological Psychiatry
2008;15(4):303-309
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: Some reports have suggested that 5-HT5A polymorphism allelic association was associated with depression, however, there has been no report about relationship between the 5-HT5A gene and antidepressant response. We conducted the association study of the 5-HT5A receptor gene polymorphisms (-19G/C,12A/T) and response to citalopram in Korean patients with major depressive disorder(MDD). METHODS: A total of 106 patients with major depressive disorder were included in this study. The patient's symptoms were measured by 21-item Hamilton Depression Rating Scale(HAMD) at baseline, week 1, week 2, week 4 and week 8 during citalopram treatment. A Responder to citalopram was defined by 50% reduction of total HAMD scores. To analyze genetic polymorphisms, a polymerase chain reaction based method was used. RESULTS: At week 8, responders were 62, non-responders were 44. No significant differences of genotypes or allelic association in 19G/C and 12A/T polymorphisms were observed between responsive and non-responsive patients. CONCLUSION: These results do not support the hypothesis that this polymorphism of the HT5A receptor gene is involved in the therapeutic response to citalopram.
