The CDH2 Gene Polymorphism in Schizophrenia.
- Author:
Won Seok LEE
1
;
Mi Kyung KIM
;
Han Yong JUNG
;
Sung Il WOO
;
Young Joon KWON
;
Jong Woo KIM
;
Hee Je LEE
Author Information
1. Seoul National Mental Hospital, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
CDH2;
Polymorphism;
Schizophrenia
- MeSH:
Gene Frequency;
Genotype;
Humans;
Korea;
Polymerase Chain Reaction;
Polymorphism, Restriction Fragment Length;
Schizophrenia*
- From:Journal of the Korean Society of Biological Psychiatry
2005;12(1):62-67
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: There has been increasing evidence that neurodevelopmental dysfunction is involved in the pathophysiology of schizophrenia. Cadherin is known to be one of the important molecules in neurodevelopment. This study was performed to examine the relationship between T816C polymorphism of CDH2 gene and schizophrenia. METHODS: Genoytypes of T816C polymorphism of CDH2 gene were analyzed by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) in 156 Korea patents with schizophrenia and 170 controls. RESULTS: No difference was found between the patients with schizophrenia and the controls in genotype and allele frequencies of T816C polymorphism of CDH2 gene. CONCLUSION: The results of this study do not support an association between T816C polymorphism of CDH2 gene and schizophrenia. However, it is necessary to investigate other polymorphic regions of CDH2 in schizophrenia.
