Relationship between Serum Inflammatory Marker and Psychotic Symptoms in Inpatients with Schizophrenia or Schizoaffective Disorder.
- Author:
Kye Hwan KIM
1
;
Kounseok LEE
;
Su Jin KIM
;
Eun Kyu LEE
;
Yul Mai SONG
;
Jin Young PARK
Author Information
1. Department of Psychiatry, Gongju National Hospital, Gongju, Korea.
- Publication Type:Original Article
- Keywords:
C-reactive protein;
Inflammatory marker;
Schizophrenia;
Positive symptoms
- MeSH:
C-Reactive Protein;
Humans;
Inpatients;
Psychopathology;
Psychotic Disorders;
Schizophrenia
- From:Journal of the Korean Society of Biological Psychiatry
2012;19(4):193-198
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: Despite the growing research interest in the role of immunological markers in schizophrenia, a few studies, with conflicting results, have focused on the association between high sensitivity C-reactive protein (hs-CRP) levels and clinical characteristics in schizophrenia. The aim of the present study was to examine the association of serum hs-CRP with psychopathology in schizophrenia. METHODS: Fifty-five inpatients with schizophrenia or schizoaffective disorder were enrolled. Serum levels of hs-CRP were measured, and each patient was assessed with the Korean version of the Positive and Negative Syndrome Scale (PANSS). RESULTS: In correlation analysis of hs-CRP with PANSS subscales, positive subscale score has significant positive correlation (r = 0.271, p = 0.046). In independent t-test analysis, subjects with hs-CRP > 0.3 mg/dL (elevated CRP group, n = 43) had significantly higher PANSS positive subscale score (t = -3.273, df = 24.107, p = 0.003) than those with hs-CRP < or = 0.3 mg/dL (normal CRP group, n = 12). CONCLUSIONS: Elevated serum levels of high sensitivity C-reactive protein in schizophrenia are associated with the severity of psychotic symptoms.
