Alterations of Cortical Folding Patterns in Patients with Bipolar I Disorder: Analysis of Local Gyrification Index.
- Author:
Junyong LEE
1
;
Kyu Man HAN
;
Eunsoo WON
;
Min Soo LEE
;
Byung Joo HAM
Author Information
1. Department of Psychiatry, Korea University Anam Hospital, Korea University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Local gyrification index;
Bipolar disorder;
Ventrolateral prefrontal cortex;
Anterior cingulate cortex;
Emotion-processing neural circuit
- MeSH:
Bipolar Disorder;
Brain;
Broca Area;
Endophenotypes;
Gyrus Cinguli;
Humans;
Magnetic Resonance Imaging;
Prefrontal Cortex
- From:Journal of the Korean Society of Biological Psychiatry
2017;24(4):225-234
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: Local gyrification reflects the early neural development of cortical connectivity, and is regarded as a potential neural endophenotype in psychiatric disorders. Several studies have suggested altered local gyrification in patients with bipolar I disorder (BD-I). The purpose of the present study was to investigate the alterations in the cortical gyrification of whole brain cortices in patients with BD-I. METHODS: Twenty-two patients with BD-I and age and sex-matched 22 healthy controls (HC) were included in this study. All participants underwent T1-weighted structural magnetic resonance imaging (MRI). The local gyrification index (LGI) of 66 cortical regions were analyzed using the FreeSurfer (Athinoula A. Martinos Center for Biomedical Imaging). One-way analysis of covariance (ANCOVA) was used to analyze the difference of LGI values between two groups adjusting for age and sex as covariates. RESULTS: The patients with BD-I showed significant hypogyria in the left pars opercularis (uncorrected-p = 0.049), the left rostral anterior cingulate gyrus (uncorrected-p = 0.012), the left caudal anterior cingulate gyrus (uncorrected-p = 0.033). However, these findings were not significant after applying the multiple comparison correction. Severity or duration of illness were not significantly correlated with LGI in the patients with BD-I. CONCLUSIONS: Our results of lower LGI in the anterior cingulate cortex and the ventrolateral prefrontal cortex in the BD-I group implicate that altered cortical gyrification in neural circuits involved in emotion-processing may contribute to pathophysiology of BD-I.
