Comparison of Cognitive Controls in Patients with Bipolar I Disorder and Their Unaffected First-Degree Relatives.
- Author:
Hyerim YUN
1
;
Seonjin WOO
;
Sang Won LEE
;
Bo Hyun JIN
;
Jungmin WOO
;
Seunghee WON
Author Information
1. Department of Psychiatry, School of Medicine, Kyungpook National University, Daegu, Korea. wonsh864@knu.ac.kr
- Publication Type:Original Article
- Keywords:
Bipolar disorder;
Cognitive control;
AX-CPT;
First-degree relatives;
Endophenotype
- MeSH:
Bipolar Disorder;
Education;
Endophenotypes;
Humans;
Intelligence;
Psychopathology;
Reaction Time
- From:Journal of the Korean Society of Biological Psychiatry
2018;25(1):9-15
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: This study intended to identify the deficits of cognitive control among patients with bipolar I disorder and their first-degree relatives, and identify the possibility of cognitive control as an endophenotype of bipolar disorder. METHODS: The study included three groups: euthymic states patients with bipolar I disorder (n = 55), unaffected first-degree relatives of probands with bipolar I disorder (n = 30), and a healthy control group (n = 51), that was matched on age, sex, and years of education. The AX version of the continuous performance test (CPT) was used to examine cognitive control. Error rate, correct response times of each subsets (AX, BX, AY, BY), and d' as an indication of accuracy sensitivity index were calculated. Psychopathology, intelligence, and psychomotor speed were also assessed. RESULTS: Patients with bipolar I disorder showed significantly worse error rates in the AX (p = 0.01) and BX (p = 0.02) subsets and d' (p = 0.05) than the others. They also showed more delayed correct response times than the healthy control group and first-degree relatives in all subsets (p < 0.01). But first-degree relatives showed neither high error rates nor delayed correct response times than healthy control group. CONCLUSIONS: These findings suggest that cognitive control is impaired in bipolar I disorder but less likely to be an endophynotype of bipolar I disorder.
