Relationship between SNP A and P1763 Polymorphisms on Dystrobrevin Binding Protein 1(DTNBP1) Gene and Smooth Pursuit Eye Movement(SPEM) Abnormality in Korean Schizophrenic Patients.
- Author:
Chang Hee LEE
1
;
Byung Lae PARK
;
Lyoung Hyo KIM
;
Dong Hyeon KIM
;
Sook Hyun CHO
;
Jin Soo PARK
;
Im Yel KIM
;
In Sang LEE
;
Han Gil SEO
;
Ki Ook BYUN
;
Bong Jo KIM
;
Kyu Hee HAHN
;
Ki Hoon KIM
;
Tae Min SHIN
;
Hyung Doo SHIN
;
Sung Il WOO
Author Information
1. Department of Psychiatry, Soon Chun Hyang University Hospital, Seoul, Korea. garakman@naver.com
- Publication Type:Original Article
- Keywords:
Schizophrenia;
Dystrobrevin binding protein 1(DTNBP1);
Smooth pursuit eye movement (SPEM);
Genetic polymorphism
- MeSH:
Alleles;
Carrier Proteins*;
DNA;
Female;
Genotype;
Humans;
Polymorphism, Genetic;
Pursuit, Smooth*;
Schizophrenia
- From:Journal of the Korean Society of Biological Psychiatry
2006;13(4):279-288
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: We investigated the association of SNP A and P1763 polymorphisms on dystrobrevin binding protein 1(DTNBP1) gene with smooth pursuit eye movement(SPEM) abnormality in Korean schizophrenic patients. METHODS: We measured SPEM function in 217 Korean schizophrenics(male 116, female 101) and divided them into two groups, one is a good SPEM function group and the other is a poor SPEM function group. We then analyzed SNP A polymorphism and P1763 polymorphism on DTNBP1 gene from their DNAs extracted from their blood. We compared the differences of genotype and allele distributions of the two polymorphisms on DTNBP1 gene between the two groups. RESULTS: The Ln S/N ratio(mean+/-SD) of the good SPEM function group was 4.39+/-0.33 and the ratio of poor SPEM function group was 3.17+/-0.71. There were no statistically significant differences of age and male/female ratio between the two groups. There were no significant differences of genotype or allele distributions of the SNP A polymorphism and P1763 polymorphism on DTNBP1 gene between the two schizophrenic groups divided by SPEM function. CONCLUSION: The results suggest that SNP A polymorphism and P1763 polymorphism on DTNBP1 gene might not be related to SPEM function abnormality in schizophrenia.
