Effect of ethylene glycol monoethyl ether on the spermatogenesis in pubertal and adult rats.
- Author:
Chang Yong YOON
;
Choong Man HONG
;
Ji Young SONG
;
Yong Yeon CHO
;
Kwang Sik CHOI
;
Beom Jun LEE
;
Cheol Kyu KIM
- Publication Type:Original Article
- Keywords:
flow cytometry;
ethylene glycol monoethyl ether;
testis;
epididymis;
DNA contents
- MeSH:
Animals;
Dose-Response Relationship, Drug;
Ethylene Glycols/*toxicity;
Male;
Organ Size/drug effects;
Rats;
Sexual Maturation/*drug effects;
Solvents/*toxicity;
Spermatogenesis/*drug effects;
Testis/drug effects/*pathology;
Time Factors
- From:Journal of Veterinary Science
2001;2(1):47-51
- CountryRepublic of Korea
- Language:English
-
Abstract:
The effects of ethylene glycol monoethyl ether (EGEE) on testicular cell populations in pubertal (5 weeks old) and adult (9 weeks old) male rats were investigated by a flow cytometric method. A total of 50 rats (in number, 25 pubertal and 25 adult rats) was divided into 5 experimental groups including 0 (control), 50, 100, 200, and 400 mg EGEE/kg of body weight. The animals were administered by gavage for 4 weeks. In adult rats, the treatment of EGEE at the dose of 400 mg/kg of body weight decreased significantly the populations of haploid, while it increased those of diploid and tetraploid cells. In pubertal rats, the treatment of EGEE at the dose of 400 mg/kg of body weight caused only minimal changes in the relative percent of testicular cell types. These results suggest that the effects of EGEE on testicular function in pubertal rats appear to be less pronounced than in adult rats.
