P50 and Schizophrenia.
- Author:
Seung Hwan LEE
1
;
Hyung Seok SEO
;
Young Cho CHUNG
Author Information
- Publication Type:Review
- Keywords: P50; Event-related potential; ERP; Schizophrenia
- MeSH: Endophenotypes; Evoked Potentials; Neurons; Schizophrenia*; Sensory Gating
- From:Journal of the Korean Society of Biological Psychiatry 2006;13(3):137-143
- CountryRepublic of Korea
- Language:Korean
- Abstract: One of the most widely recognized neurophysiologic endophenotypes for schizophrenia is deficient gating or inhibition of the P50 component of the auditory event-related potential(ERP). A deficit in P50 sensory gating refers to a dysfunction in the mechanism responsible for modulating the brain's sensitivity of filtering out irrelevant or background stimuli, perhaps as a result of dysfunction in inhibitory neural circuits. In this paper, we review the neuronal and genetic aspects as well as medication effects on P50 in schizophrenia.
