Association between Social Phobia and Serotonin Transporter Gene Polymorphism: Preliminary Study.
- Author:
Jae Hon LEE
1
;
Se Won LIM
;
Kang Seob OH
;
Min Soo LEE
Author Information
1. Department of Psychiatry, Kangbuk Samsung Hospital, Sungkyunkwan University, School of Medicine, Seoul, Korea. ks2485@empal.com
- Publication Type:Original Article
- Keywords:
Social phobia;
Serotonin trasporter(5-HTT);
Polymorphism
- MeSH:
Alleles;
Gene Frequency;
Genotype;
Phobic Disorders*;
Serotonin Plasma Membrane Transport Proteins*;
Serotonin*
- From:Journal of the Korean Society of Biological Psychiatry
2006;13(3):170-177
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
ele frequency analysis, a significant association was also observed between the short allele and social phobia(p=.030). A significant associations between S genotype and each subgroup were observed(GEN p=.045 ; NGEN p=.033), but there were no differences in allele frequency. And, no differences in genotype and allele distribution between two subgroups were found. CONCLUSION: The results in our Korean sample suggest that S genotype of 5-HTTLPR may be associated with social phobia and s allele may be an important genetic factor that activates social phobic symptoms. But, further studies including large number of samples are necessary to elucidate these present findings.
