Relationship between Alcohol Withdrawal Symptoms and Dopaminergic Gene Polymorphisms(DRD2, DAT, COMT) in Alcohol Dependence Patients.
- Author:
Tai Young CHOI
1
;
Ho Nam KIM
;
Doug Hyun HAN
;
Kyung Jun MIN
;
Young Sik LEE
;
Chul NA
Author Information
1. Department of Neuropsychiatry, Chung-Ang University School of Medicine, Seoul, Korea. hawkeyelys@hanmail.net
- Publication Type:Original Article
- Keywords:
Alcohol withdrawal;
Genetic polymorphism;
CIWA-Ar
- MeSH:
Alcoholism*;
Alleles;
Heterozygote;
Homozygote;
Humans;
Polymorphism, Genetic;
Substance Withdrawal Syndrome*
- From:Journal of the Korean Society of Biological Psychiatry
2006;13(3):178-190
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
with DAT-9 gene allele. And The total score of CIWA-Ar scale in the subject without DAT-9 gene allele was significantly higher than in the subject with DAT-9 gene allele. COMT: The total score of CIWA-Ar scale in heterozygote was significantly higher than in homozygote. CONCLUSION: Our results suggest the relationship between specific genetic factors and the withdrawal symptoms of alcohol dependent patients. As the candidate gene of the severity of alcohol withdrawal syndrome, DRD2 Taq1 gene was recommended.
