Prophylactic effect of plaster and cataplasm contained ketoprofen in rats with adjuvant arthritis.
- Author:
Seong Soo KANG
;
Seok Hwa CHOI
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Adjuvant arthritis;
plaster;
cataplasm;
ketoprofen
- MeSH:
Animals;
Anti-Inflammatory Agents, Non-Steroidal/*pharmacology;
Arthritis, Experimental/*prevention & control;
Calcium Sulfate;
Drug Carriers/administration & dosage;
Excipients/*administration & dosage;
Female;
Freund's Adjuvant;
Ketoprofen/*administration & dosage/analogs & derivatives/therapeutic use;
Rats;
Rats, Sprague-Dawley
- From:Journal of Veterinary Science
2001;2(1):65-70
- CountryRepublic of Korea
- Language:English
-
Abstract:
This study demonstrates that prophylactic effect of plaster and cataplasm contained ketoprofen in adjuvant arthritis therapy by X-ray. Adjuvant arthritis was induced by a single injection of Freund's complete adjuvant. Mature female Sprague-Dawley rats were designated to 3 groups such as nontreated control, plaster-treated (PT) and cataplasm-treated (CT), each of which was composed of ten animals. The PT and the CT groups showed reduced primary paw swelling, but secondary paw swelling was not affected. Bony changes were observed in all regions of the femur and tibia of the nonadjuvant-injected leg and the adjuvant-injected leg. The mean radiographic scores of the PT and the CT groups were significantly lower than those of the control group from day 0 to 7 of the experimental period (p<0.05, p<0.01). The CT rats showed reduced poly-arthritis development than the PT rats. Our results suggest that radiographic assessment of bony changes is more suitable for measuring changes in long bones such as femur or tibia than in vertebrae. The prophylactic effect of CT prominently suppressed edematous swelling and bony changes in arthritic limb compared with PT.
