An Overview of Psychoneuroimmunology.
- Author:
Do Hoon KIM
1
Author Information
1. Department of Psychiatry, Hallym University College of Medicine, Chuncheon Sacred Heart Hospital, Chuncheon, Korea. dohkim@hallym.ac.kr
- Publication Type:Review
- Keywords:
Psychoneuroimmunology;
Neural-immune interactions;
Stress
- MeSH:
Acetylcholine;
Body Temperature;
Brain;
Histamine;
Immune System;
Nervous System;
Neurotransmitter Agents;
Norepinephrine;
Psychoneuroimmunology;
Substance P
- From:Journal of the Korean Society of Biological Psychiatry
2008;15(3):147-151
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
This review briefly summarizes the relevant knowledge of psychoneuroimmunological basis for neuroimmunology, with particular emphasis on bidirectional neural-immune interactions. The immune system and the nervous system maintain extensive communication, including hardwiring of sympathetic and parasympathetic nerves to lymphoid organs. Immune system is modulated by various neurotransmitters such as acetylcholine, norepinephrine, substance P and histamine. Neuroendocrine hormones such as corticotrophin-releasing hormone(CRH) or substance P regulate cytokine balance. The immune system modulates brain activity including sleep and body temperature. Recent studies have revealed that psychological factors which influence immunity and immune-related disease may modulate brain-to -immune interaction. But, we still await the scientific research and evidences to prove whether or how behavioral or treatment intervention of stress can influence the development, progress or prevention of a specific disease.
