Depression and Coronary Artery Disease(I): Pathophysiologic Mechanisms.
- Author:
Kyung Yeol BAE
1
;
Jae Min KIM
;
Jin Sang YOON
Author Information
1. Department of Psychiatry, Chonnam National University Medical School and Depression Clinical Research Center, Chonnam National University Hospital, Gwangju, Korea.
- Publication Type:Review
- Keywords:
Depression;
Coronary artery disease;
Pathophysiologic mechanism
- MeSH:
Autonomic Nervous System;
Axis, Cervical Vertebra;
Coronary Artery Disease;
Coronary Vessels;
Depression;
Heart;
Humans;
Prognosis;
Thrombophilia
- From:Journal of the Korean Society of Biological Psychiatry
2008;15(4):275-287
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Depression and coronary artery disease are both highly prevalent diseases. Many previous studies suggest that depression is a common comorbid condition in patients with coronary artery disease and has a significant negative impact on the onset, course, and prognosis of coronary artery disease. However, the exact mechanisms that underlie the association between these two diseases remain unclear. Pathophysiologic mechanisms that may explain the effect of depression on coronary artery disease include hypercoagulability, hypothalamus-pituitary-adrenal axis and autonomic nervous system dysregulation, altered inflammatory response. On the contrary, pathophysiologic mechanisms in coronary artery disease that affect depression are less well known. It is also suggested that both diseases may share a common genetic vulnerability. The authors reviewed the literature on the pathophysiologic relationships of depression and coronary heart disease.
