No Association between Val108/158Met Polymorphism on Catechol-O-Methyl Transferase(COMT) Gene and Smooth Pursuit Eye Movement(SPEM) Abnormality in Korean Schizophrenia Patients.
- Author:
Ho Joon JANG
1
;
Hyun Il MOON
;
Yeon Jung LEE
;
Im Yel KIM
;
In Sang LEE
;
Han Gil SEO
;
Ki Hoon KIM
;
Tae Min SHIN
;
Byung Lae PARK
;
Hyung Doo SHIN
;
Sun Ho HAN
;
Sang Woo HAN
;
Sung Il WOO
Author Information
1. Department of Neuropsychiatry, College of Medicine, Soonchunhyang University, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Schizophrenia;
Catechol-O-methyl transferase(COMT);
Smooth pursuit eye movement(SPEM);
Genetic polymorphism
- MeSH:
Alleles;
Eye;
Female;
Genotype;
Humans;
Polymorphism, Genetic;
Pursuit, Smooth;
Schizophrenia
- From:Journal of the Korean Society of Biological Psychiatry
2008;15(4):288-296
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: We investigated the association of Val108/158Met polymorphism on catechol-O-methyl transferase(COMT) gene with smooth pursuit eye movement(SPEM) abnormality in Korean schizophrenia patients. METHODS: We measured SPEM in 217 Korean schizophrenia patients(male 116, female 101) and divided them into two groups, one was a good SPEM function group and the other was a poor SPEM function group. Then we analyzed Val108/158Met polymorphism on COMT gene. We compared the differences of genotype and allele distributions of the polymorphism on COMT gene between the two groups. RESULTS: The natural logarithm value of signal/noise ratio(Ln S/N ratio) of the good SPEM function group was 4.39+/-0.33(mean+/-s.d.) and that of poor SPEM function group was 3.17+/-0.71. There were no statistically significant differences of age and male/female ratio between the two groups. There were no significant differences of genotype or allele distributions of the Val108/158Met polymorphism on COMT gene between the two schizophrenic groups. CONCLUSIONS: The results suggest that Val108/158Met polymorphism on COMT gene is not related to SPEM function abnormality in schizophrenia.
