Conduction Abnormalities and Associated Factors in Korean Patients with Eating Disorders.
- Author:
Sang Bin BAE
1
;
Joon Hyung DOH
;
Youl Ri KIM
Author Information
1. Department of Psychiatry, Inje University Seoul Paik Hospital, Inje University College of Medicine, Seoul, Korea. youlri.kim@paik.ac.kr
- Publication Type:Original Article
- Keywords:
Eating disorders;
Complication;
Conduction abnormalities;
QT interval;
QT dispersion
- MeSH:
Amylases;
Anorexia;
Anorexia Nervosa;
Arrhythmias, Cardiac;
Body Mass Index;
Bulimia Nervosa;
Death, Sudden;
Eating;
Feeding and Eating Disorders;
Electrocardiography;
Female;
Humans;
Retrospective Studies;
Weight Loss
- From:Journal of the Korean Society of Biological Psychiatry
2012;19(1):38-44
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: QT interval prolongation and dispersion known as indicators of an increased risk for ventricular arrhythmias and sudden death have been reported to be prolonged in patients with anorexia nervosa. The aims of this study were to compare conduction abnormalities in Korean patients with anorexia nervosa and bulimia nervosa, and to examine its relation with clinical and laboratory factors. METHODS: We retrospectively examined 45 women with anorexia nervosa and 75 women with bulimia nervosa who were assessed by 12-lead electrocardiogram at baseline. QT interval and corrected QT interval, QT dispersion of the difference between the longest and shortest QT intervals, and abnormal U wave were measured for conduction abnormalities. RESULTS: QT interval was significantly longer in patients with anorexia nervosa compared with those with bulimia nervosa. There were no differences in QTc (Corrected QT), QTd (QT dispersion) and abnormal U wave between patients with anorexia nervosa and those with bulimia nervosa. QTd was significantly correlated with the lowest ever lifetime body mass index (kg/m2) as well as the serum amylase level in patients with anorexia nervosa. CONCLUSIONS: These results suggest some conduction abnormalities reported in patients with anorexia nervosa are also found in patients with bulimia nervosa. It appears that severity of weight loss and purging behavior could affect the cardiac arrhythmia in patients with eating disorders. Appropriate attention should be paid to cardiac involvement in patients with eating disorders.
