Association Study between DRD2 Genetic Polymorphisms and Schizophrenia in a Korean Population.
- Author:
Tae Sung KIM
1
;
Seung Min CHA
;
Seong Keun WANG
;
Jeong Lan KIM
;
Young Ho LEE
;
Hye In CHOI
;
Ik Seung CHEE
Author Information
1. Department of Psychiatry, Chungnam National University Hospital, Daejeon, Korea.
- Publication Type:Original Article
- Keywords:
Schizophrenia;
DRD2;
Genetic polymorphism;
Association study
- MeSH:
Alleles;
Genotype;
Humans;
Polymorphism, Genetic;
Receptors, Dopamine D2;
Schizophrenia
- From:Journal of the Korean Society of Biological Psychiatry
2012;19(1):53-57
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: This study was designed to investigate the association between the dopamine D2 receptor (DRD2) genetic polymorphism [TaqIB (rs17294542) and TaqID (rs1800498)] and patients with schizophrenia. METHODS: TaqIB (rs17294542) and TaqID (rs1800498) polymorphism of the DRD2 gene were typed in 100 patients with schizophrenia and 109 normal controls. RESULTS: There were no statistical differences in genotype and allele distribution of TaqIB (rs17294542) and TaqID (rs1800498) genetic polymorphism between patients with schizophrenia and normal controls. CONCLUSIONS: These results suggest that the TaqIB (rs17294542) and TaqID (rs1800498) polymorphisms of the DRD2 gene may not be associated with schizophrenia in the Korean population.
