Sex Differences in Cerebellar Structure of Healthy Adults.
- Author:
Jihyun H KIM
1
;
Sujin BAE
;
Keun Taik RYU
;
Min Seong KANG
;
Soo Mee LIM
;
Sunho LEE
;
Sojin LEE
;
Eun KO
;
Do Un JEONG
Author Information
1. Department of Psychiatry, Daegu Catholic University Medical Center, Daegu, Korea.
- Publication Type:Original Article
- Keywords:
Cerebellum;
Magnetic resonance imaging
- MeSH:
Adult;
Brain;
Cerebellum;
Female;
Humans;
Magnetic Resonance Imaging;
Male;
Neuroimaging;
Sex Characteristics
- From:Journal of the Korean Society of Biological Psychiatry
2012;19(2):77-83
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: Although there have been studies that examine sex differences of the brain structures using magnetic resonance imaging, studies that specifically investigate cerebellar structural differences between men and women are scarce. The purpose of current study was to examine sex differences in structures of the cerebellum using cerebellar template and cerebellum analysis methods. METHODS: Sixteen men and twenty women were included in the study. A MATLAB based program (MathWorks, Natick, MA, USA), Statistical Parametric Mapping 5 (SPM5) using the spatially unbiased infra-tentorial atlas template (SUIT) as the cerebellum template, was used to analyze the brain imaging data. RESULTS: There was no significant difference in age between men (mean age = 28.1) and women (mean age = 27.2). Men showed higher gray matter density than women in two left cerebellar areas including the clusters in the lobules IV and V (a cluster located across the lobules IV and V), and the lobule VIIIb (lobules IV and V, t = 4.75, p < 0.001 ; lobule VIIIb, t = 3.08, p = 0.004). CONCLUSIONS: The current study found differences in cerebellar gray matter density between men and women. The current study holds its significance for applying the template specifically developed for the analysis of cerebellum.
