Association Analysis of Neuregulin 3 Gene with Schizophrenia in a Korean Population.
- Author:
Sujin SHIN
1
;
Jong Taek CHOI
;
Ji Won KIM
;
Yang Ho ROH
;
Byung Lae PARK
;
Joon Seol BAE
;
Hyoung Doo SHIN
;
Ihn Geun CHOI
;
Sang Woo HAN
;
Jaeuk HWANG
;
Sung Il WOO
Author Information
1. Department of Psychiatry, College of Medicine, Soonchunhyang University, Soonchunhyang University Hospital, Seoul, Korea. siwoo@schmc.ac.kr
- Publication Type:Original Article
- Keywords:
NRG3;
Schizophrenia;
Single nucleotide polymorphism;
rs2295933
- MeSH:
Asian Continental Ancestry Group;
Case-Control Studies;
Cohort Studies;
Exons;
Humans;
Jews;
Logistic Models;
Polymorphism, Single Nucleotide;
Schizophrenia;
Wills
- From:Journal of the Korean Society of Biological Psychiatry
2012;19(3):128-133
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: Located on chromosome 10q22-q23, the human neuregulin 3 (NRG3) is suggested as a strong positional and functional candidate gene involved in the pathogenesis of schizophrenia. Several case-control studies examining the association between polymorphisms on NRG3 gene with schizophrenia and/or its traits (such as delusion) have been reported recently in cohorts of Han Chinese, Ashkenazi Jews, Australians, white Americans of Western European ancestry and Koreans. Thus, this study aimed to investigate the association of one SNP in exon 9 (rs2295933) of NRG3 gene with the risk of schizophrenia in a Korean population. METHODS: Using TaqMan assay, rs2295933 in the exon 9 of NRG3 was genotyped in 435 patients with schizophrenia as cases and 393 unrelated healthy individuals as controls. Differences in frequency distributions were analyzed using logistic regression models following various modes of genetic inheritance and controlling for age and sex as covariates. RESULTS: Subsequent analysis revealed that the frequency distribution of rs2295933 of NRG3 was not different between schizophrenia patients and healthy controls of Korean ethnicity. CONCLUSIONS: This study does not support the role of NRG3 in schizophrenia in a Korean population.
