The Alteration of Carbohydrate-Deficient Transferrin and Nerve Growth Factor in the Patients with Alcohol Dependence.
- Author:
Chan Min JEON
1
;
Boung Yang PARK
;
Jung Hyun BYUN
;
Boung Chul LEE
;
Byung Joo HAM
;
Mina HUR
;
Ihn Geun CHOI
Author Information
1. Department of Neuropsychiatry, College of Medicine, Hallym University, Chuncheon, Korea. ihngeun@hallym.or.kr
- Publication Type:Original Article
- Keywords:
Alcohol dependence;
Carbohydrate-deficient transferrin;
Nerve growth factor;
Neurotoxicity
- MeSH:
Alcohol Abstinence;
Alcoholism*;
Biomarkers;
Humans;
Models, Animal;
Nerve Growth Factor*;
Transferrin*
- From:Journal of the Korean Society of Biological Psychiatry
2007;14(3):161-166
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: Recent studies have raised the possibility that nerve growth factor(NGF) is abnormally regulated in the central nervous system(CNS) of animal models with alcohol dependence. The possible alteration of NGF by prolonged alcohol intake may play an important role in alcohol-induced neurotoxicity. Carbohydrate-deficient transferrin(CDT) is regarded as a reliable biological marker of alcohol dependence. The goal of this study was to estimate the changes of %CDT and serum NGF level according to the duration of alcohol abstinence, and to identify whether %CDT level is associated with the serum NGF level in the patients with alcohol dependence. METHODS: The subjects were 24 patients with alcohol dependence. We used the Axis-Shield ASA to measure the %CDT level and the enzyme-linked immunosorbent assay(ELISA) to measure the serum NGF level. %CDT and NGF levels were measured immediately after the admission and at 2 weeks after the admission. RESULTS: Decreased %CDT were observed during the period of 2 weeks after the admission. NGF level was not significantly different after 2 weeks. The NGF levels were not correlated with %CDT. The possibility of %CDT as a predictor of alcohol-induced neurotoxicity was not confirmed. CONCLUSION: Serum NGF levels is not a reliable indicator of abstinence state in the patients with alcohol dependence. Further studies are needed to evaluate the relation between two indicators in regard to hematological and neurological changes in alcohol dependence.
