No Association between the 5-HT6 Receptor C267T Polymorphism and Response to Citalopram Treatment in Patient with Major Depressive Disorder.
- Author:
Sang Woo HAHN
1
;
Se Won LIM
;
Kang Seob OH
;
Rhee Hun KANG
;
Min Soo LEE
Author Information
1. Department of Psychiatry, Soonchunhyang University of College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
Major depressive disorder;
5-HT6 receptor;
C267T polymorphism;
Citalopram
- MeSH:
Alleles;
Antidepressive Agents;
Citalopram*;
Depression;
Depressive Disorder, Major*;
Genotype;
Humans;
Outcome Assessment (Health Care);
Serotonin
- From:Journal of the Korean Society of Biological Psychiatry
2007;14(4):262-267
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The serotonin 6(5-HT6) receptor gene is a candidate gene for influencing the clinical response to treatment with antidepressants. The purpose of this study was to determine the relationship between the C267T polymorphism in the 5-HT6 receptor gene and the treatment response to citalopram in a Korean population with major depressive disorder(MDD). METHODS: Citalopram was administered for 8 weeks to the 90 patients who completed study. 21-item Hamilton depression rating scale(HAMD-21) was used as a outcome measure. RESULTS: We found that the genotype, allele, and allele-carrier distributions did not differ significantly between MDD patients and normal controls. A main effect of an interaction of genotype with time on the decrease in the HAMD-21 score during the 8 weeks study period was not found. ANOVA revealed no significant effects of the C825T polymorphism on the decrease in the HAMD-21 score at each time period. CONCLUSIONS: These results suggest that the C267T polymorphism in the 5-HT6 receptor gene is not associated with the treatment response to citalopram.
