An Association Between Apolipoprotein E epsilon4 and Cognitive Function in Community-Dwelling Elders with Questionable Dementia.
- Author:
Seok Woo MOON
1
;
Jeong Seok SEO
;
Beom Woo NAM
;
Jin Young CHOI
;
Chang Hoon LEE
;
Kyoung Un PARK
;
Ki Woong KIM
Author Information
1. Department of Neuropsychiatry, School of Medicine Kunkuk University, Chungju Hospital, Chungju, Korea.
- Publication Type:Original Article
- Keywords:
CDR;
Apolipoprotein E;
CERAD-K;
Neuropsychological test
- MeSH:
Aged;
Alleles;
Apolipoproteins;
Apolipoproteins E;
Dementia;
Deoxycytidine;
DNA;
Humans;
Neuropsychological Tests
- From:Journal of the Korean Society of Biological Psychiatry
2008;15(1):5-13
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVES: It was the aim of the present paper to examine the impact of the apolipoprotein E(APOE) epsilon4 on cognitive performance in community-dwelling elderly samples with'questionable dementia'. METHODS: Total 295 samples who were diagnosed with'questionable dementia'in the recent year and completed the Korean version of the Consortium Establish a Registry for Alzheimer's Disease(CERAD-K) neuropsychological assessment protocol, were recruited. The CDR test established score of 0.5. Genomic DNA was extracted from the venous blood and APOE genotyping was done in this group. Their cognitive performance was compared by the occurrence of the APOE epsilon4 allele. RESULTS: The impact of epsilon4 allele was significant in the Word List Recall Test(WLRT, F=4.511, df=1, p=0.035). The'young-old' group aged 75 years and under had a significantly lower performance on the Word List Recall Test(WLRT, F=5.090, df=1, p=0.015), but the'old-old'group over 75 years of age had not significantly different performance on the all the item of tests in epsilon4+ allele group. CONCLUSION: The conclusion to be drawn here is that community-dwelling elderly samples with epsilon4 allele in 'questionable dementia' had a significantly lower performance on the Word List Recall Test in the CERAD-K neuropsychological test batteries and the effect was prominent in the 'young-old' age group.
