Changes of Interleukin-12 and Transforming Growth Factor Beta 1 before and after Antipsychotic Treatments in Schizophrenic Patients.
- Author:
Sung Jae KIM
1
;
Bun Hee LEE
;
Yong Ku KIM
Author Information
1. Department of Psychiatry, College of Medicine, Korea University, Ansan Hospital, Ansan, Korea. yongku@korea.ac.kr
- Publication Type:Original Article
- Keywords:
Cytokine;
Interleukin;
TGF;
Schizophrenia
- MeSH:
Enzyme-Linked Immunosorbent Assay;
Humans;
Interleukin-12*;
Interleukins;
Plasma;
Psychopathology;
Schizophrenia;
Transforming Growth Factor beta*;
Transforming Growth Factor beta1;
Transforming Growth Factors*
- From:Journal of the Korean Society of Biological Psychiatry
2005;12(2):143-150
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Several reports have suggested that cytokine alterations could be related to the pathophysiology of schizophrenia. In this study, we measured plasma level of interleukin-12(IL-12), a pro-inflammatory T helper 1(Th1) cytokine and transforming growth factor-beta1(TGF-beta1), an anti-inflammatory Th3 cytokine before and after antipsychotic treatment in schizophrenic patients. METHODS: The plasma concentrations of IL-12 and TGF-beta1 were measured by using quantitative ELISA in 23 schizophrenic patients and 31 normal controls at admission and 8 weeks later. The psychopathology was measured by Brief Psychiatric Rating Scale(BPRS). RESULTS: IL-12 and TGF-beta1 levels were significantly higher in schizophrenic patients than in controls before treatment. At the 8 week of treatment, the TGF-beta1 levels returned to control values, while IL-12 levels were not significantly changed. There were no significant correlations between the changes of BPRS scores and the changes of IL-12 or TGF-beta1 levels in schizophrenic patients. CONCLUSION: Cytokine abnormalities in schizophrenia might be involved in the pathophysiology of the illness. It is possible that TGF-beta1 plays an important role in the schizophrenia.
